Overview

        XYZ2CPC is a personalized transcranial magnetic stimulation (TMS) target planning software designed to provide clinicians and researchers with a practical solution for individualized TMS targeting without the need for neuronavigation equipment. The core function of the software is to convert individual brain target coordinates (XYZ) into Continuous Proportional Coordinates (CPC) on the individual scalp surface. Using these CPC coordinates, operators can quickly and precisely locate personalized cortical targets through simple tape measurements on the scalp.

        The software provides a complete workflow for personalized TMS target planning: structural MRI visualization and interaction, deep learning-based automatic scalp segmentation and 3D reconstruction, interactive anatomical landmark identification, CPC coordinate system computation, cortical target planning with optimal scalp CPC coordinate calculation, and visualization and export of planning results.

        XYZ2CPC is applicable to various clinical and research scenarios, including individualized TMS treatment for depression based on DLPFC-SGC functional connectivity, hippocampal network-targeted stimulation for Alzheimer’s disease, personalized motor cortex localization for stroke rehabilitation, and other neuromodulation studies requiring individualized cortical targeting. The primary users include clinicians implementing personalized TMS protocols, neuroscience researchers, and healthcare institutions with limited resources seeking to deliver precision TMS therapy.